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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- er-stress-neurodegeneration
IRE1α–XBP1 Pathway IRE1α is the most evolutionarily conserved [endoplasmic
Read more → - Endoplasmic Reticulum Stress Comparison Across Neurodegenerative Diseases
IRE1α, PERK, ATF6 | IRE1α, PERK | IRE1α, PERK, ATF6 | IRE1α, PERK
Read more → - upr
IRE1α Pathway IRE1α is the most evolutionarily ancient UPR sensor
Read more → - CBS ER Stress and Unfolded Protein Response Mechanisms
IRE1α luminal domain upon GRP78 release - Trans-autophosphorylation of kinase
Read more → - CASP12 (Caspase-12)
IRE1α, and ATF6—detect protein misfolding and initiate adaptive responses
Read more →
Graph neighborhood (3 nodes · 3 edges)
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Related hypotheses
- H4: Hyperconnected Hub Status Creates Proteostatic Traffic Jams
starts from the claim that modulating ERN1 (IRE1α), TFG, ATG9A within the disease context ... starts from the claim that modulating ERN1 (IRE1α), TFG, ATG9A within the disease con…
- NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitophagy to ER-Phagy
involves the unfolded protein response (UPR) sensors IRE1α, PERK, and ATF6. NAD+ depletion affects ... leading to ER stress and UPR activation. IRE1α undergoes autophosphorylation…
- H3: APOE4 Impairs Cholesterol Trafficking, Triggering Astrocyte Senescence
response (UPR). Specifically, inositol-requiring enzyme 1α (IRE1α), protein kinase R-like ER kinase (PERK ... transcription factor 6 (ATF6) become chronically activated. IRE1α act…
- Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective Effector
specifically via the inositol-requiring enzyme 1α (IRE1α)-X-box binding protein 1 (XBP1) branch ... IRE1α-XBP1s pathway directly transactivates MANF expression through XBP1 bindin…
- Lipid Droplet Dynamics as Phenotype Switches
interaction with the endoplasmic reticulum stress sensor IRE1α, promoting the unfolded protein response and inflammatory