No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Disease-Associated Microglia Type 2 (DAM2)
Itgax+ Itgax+/- Cx3cr1+ Tyrobp+ Cst7+ Cst7+/- Tmem119+ Lpl+ Lpl++ Lpl+++ ``` ### TREM2
Read more → - CBS Microglial Neuroimmune Axis
Itgax) 2. **Stage 2 (DAM)**: Full activation of a disease
Read more → - TREM2 Protein — Triggering Receptor Expressed on Myeloid Cells 2
ITGAX (CD11c), APOC1, SPP1 | Aggregate clearance | ### DAM Transition Pathway The transition
Read more → - Neurodegeneration-Associated Microglia (NAM)
ITGAX CD11c Feature DAM (Stage 1-2) TREM2 Intermediate APOE
Read more → - MITF Gene — Microphthalmia-Associated Transcription Factor
ITGAX"] D --> D1["LC3, BECN1, SQSTM1"] E --> E1["IL10, TGFB
Read more →
Graph neighborhood (6 nodes · 7 edges)
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Related hypotheses
- Downstream Pathway Selective Modulation: ITGAX (αXβ2) Integrin Blockade
Mechanistic Overview Downstream Pathway Selective Modulation: ITGAX (αXβ2) Integrin Blockade starts from the claim that ... modulating ITGAX (CD11c) within the disease context of …
- Cell-Type Specific TREM2 Upregulation in DAM Microglia
lipoprotein lipase), SPP1 (osteopontin), CD9, GPNMB, ITGAX (CD11c), CLEC7A (Dectin-1), AXL, LGALS3 (galectin
- HK2-Dependent Metabolic Checkpoint as the Gatekeeper of DAM Transition
with inflammatory mediators including **TREM2**, **APOE**, **CX3CR1**, **ITGAX (CD11c)**, and **CLEC7A**. The correlation with TREM2
- sTREM2 as Biomarker of Cystatin-C Therapeutic Efficacy
together with **APOE**, **LPL**, **CSF1**, **CD68**, and **ITGAX** (CD11c). This shift is most pronounced
- PLCG2 Allosteric Modulation as a Precision Therapeutic for TREM2-Dependent Microglial Dysfunction
program, alongside **TREM2**, **TYROBP**, **CSF1R**, **ITGAX**, and **APOE**. The **PLCG2** P522R variant (rs72824905) is reproducibly