LC3

Wiki pages (5)

SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.

• LC3 Protein

  LC3["LC3"] SQSTM1["SQSTM1"] -->|"binds"| LC3["LC3"] LC3["LC3"] -->|"regulates

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• MAP1LC3A Gene

  LC3 to generate LC3-I - Atg4B is the primary protease

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• LC3 (MAP1LC3) Neurons

  LC3 as a Research Tool ### LC3 Puncta Analysis LC3 immunofluorescence

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• LC3 (Microtubule-Associated Protein 1 Light Chain 3)

  LC3 LC3 -->|"regulates"| LC3_associated_phagocytosis LC3 -->|"regulates"| LC3_associated

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• MAP1LC3A Gene

  LC3["LC3"] AUTOPHAGY["AUTOPHAGY"] -.->|"inhibits"| LC3["LC3"] AUTOPHAGY["AUTOPHAGY"] -->|"associated

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Graph neighborhood (30 nodes · 190 edges)

Related hypotheses

• MFN2-PACS2 Axis at MAMs Coordinates Mitophagy-ER-Phagy Sync

  selective autophagy receptor through its LC3-interacting region (LIR) motif located in the C-terminal ... This LIR motif enables direct binding to LC3-II and GABARAP subfamily pro…

• APOE-Dependent Autophagy Restoration

  enlarged multivesicular bodies, impaired autophagic flux (elevated LC3-II/LC3-I ratio with p62 accumulation ... improving trial efficiency. Candidate biomarkers include blood LC3-…

• Autophagosome Maturation Checkpoint Control

  occurs through a sophisticated spatiotemporal mechanism involving LC3-II (microtubule-associated protein 1A/1B-light chain ... terminal domain contains a specialized LC3-interacti…

• Transcriptional Autophagy-Lysosome Coupling

  phagophore nucleation - ATG5-ATG12-ATG16L complex promotes LC3 lipidation and membrane expansion - BECN1 (Beclin ... hippocampus), tau hyperphosphorylation reduced by 40% - LC3-II…

• VCP-Mediated Autophagy Enhancement

  interaction with the autophagy machinery, including LC3, SQSTM1/p62, and the ESCRT complexes, while maintaining selectivity ... enhanced VCP activity accelerates the conversion of…