No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- LDLR Gene
LDLR["LDLR"] PCSK9["PCSK9"] -.->|"inhibits"| LDLR["LDLR"] h_b948c32c["h-b948c32c
Read more → - LDL Receptor Protein
LDLR**: Classic LDL receptor - **LDLR-related protein 1 (LRP1)**: Larger
Read more → - LDLR Protein (Low-Density Lipoprotein Receptor)
LDLR) is a transmembrane glycoprotein encoded by the LDLR gene
Read more → - LDLRAP1 — Low Density Lipoprotein Receptor Adaptor Protein 1
LDLR LDLR -->|"regulates"| CHOLESTEROL SREBF2 -->|"transcriptionally activates"| LDLR LDLR -->|"interacts
Read more → - LDLRAD3 (LDLR Adapter Protein 1) Protein
LDLR["LDLR LDL Receptor"] APOE["APOE Apolipoprotein E"] OxStress["Oxidative
Read more →
Graph neighborhood (30 nodes · 116 edges)
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Related hypotheses
- LDLR Ligand-Binding Domain A Fusion for Receptor-Mediated Transcytosis
Rationale** The low-density lipoprotein receptor (LDLR) represents a promising gateway for therapeutic delivery across ... brain barrier through receptor-mediated transcytosis. T…
- APOE4-Specific Microglial Metabolic Rescue
from the claim that modulating APOE, ABCA1, LDLR within the disease context of neurodegeneration ... from the claim that modulating APOE, ABCA1, LDLR within the disease context of…
- APOE4 astrocytes fail to supply sufficient cholesterol to parvalbumin interneurons, causing presynaptic GABA release deficits, disinhibition, and network hyperexcitability characteristic of AD
starts from the claim that modulating LDLR, LRP8 (ApoER2), APOE within the disease context ... starts from the claim that modulating LDLR, LRP8 (ApoER2), APOE within the disease c…
- Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
starts from the claim that modulating HMGCR, LDLR, APOE regulatory regions within the disease context ... dependent on astrocyte-derived cholesterol delivered via LDLR family rece…
- FcRn Transport Bypass Strategy
Strategy starts from the claim that modulating LDLR within the disease context of neuropharmacology ... protein 1 (LRP1), low-density lipoprotein receptor (LDLR), or insulin recep…