No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Liver X Receptor (LXR) Signaling in Neurodegeneration
LXRβ Agonists LXRβ-selective activation may provide neuroprotection without peripheral
Read more → - LXR Protein (Liver X Receptor)
LXRβ NR1H2 Gene Variant Effect NR1H3 (LXRα) variants Altered activity
Read more → - cyp46a1-protein
LXRβ) sense oxysterol levels (including 24HC) and induce CYP46A1 expression
Read more → - Microglia-State Editing via TREM2-LXR Pulse Program
LXRβ agonists, negotiate access | 2 months | $25,000 (BD costs
Read more → - Microglia-State Editing via TREM2-LXR Pulse Program
LXRβ agonist) | Phase 1 | 48 | Healthy volunteers | Safety, lipid levels
Read more →
Graph neighborhood (7 nodes · 8 edges)
Click a neighbor to navigate · double-click opens in a new tab · open in full graph viewer
Related hypotheses
- LXRβ-Selective Agonism as a Precision Therapeutic for APOE4-Driven Myelin Deficits
Mechanistic Overview LXRβ-Selective Agonism as a Precision Therapeutic for APOE4-Driven Myelin Deficits starts ... from the claim that modulating NR1H2 (LXRβ) within the disease c…
- Selective LXRβ agonists restore ABCA1/ABCG1 expression and APOE lipidation in APOE4 astrocytes, normalizing cholesterol export and reducing AD-relevant neurotoxicity
basis for selective liver X receptor beta (LXRβ/NR1H2) agonism in Alzheimer's disease centers ... impaired cholesterol homeostasis in APOE4-expressing astrocytes. LXRβ functions a…
- LXRβ-Selective Agonism Enhances CYP2J2-Mediated DHA Epoxide Generation to Restore Synaptic Membrane Homeostasis in Alzheimer's Disease
This hypothesis proposes that LXRβ-selective agonists enhance CYP2J2 expression and activity to increase protective ... through direct transcriptional control. By selectively acti…
- LXRβ-Selective Agonism to Simultaneously Enhance APOE Lipidation and Reduce Microglial Cholesterol Accumulation
LXRβ-selective agonism represents a targeted strategy to simultaneously enhance APOE lipidation and reduce microglial ... approach exploits the predominant CNS expression of LXRβ …
- CYP2J2-Generated DHA Epoxides Enhance LXRβ-Mediated APOE Lipidation for Synergistic Synaptic Protection
CYP2J2-generated DHA epoxides act as endogenous LXRβ agonists, creating a synergistic mechanism for synaptic ... rigidification through membrane incorporation, while simultaneousl…