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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Astrocyte Metabolic Enhancement Therapy for PD
MCT4 Overexpression Studies Viral vector-mediated overexpression of MCT4 in astrocytes
Read more → - Metabolic Coupling and the Energy Substrate of Computation
MCT4 are expressed on astrocytes and on the vascular side
Read more → - Astrocyte-Neuron Metabolic Coupling Pathway
MCT4 | Transporter | Astrocytic lactate export | Activity-dependent[@kimelberg2021] | | MCT2 | Transporter
Read more → - Validated Hypothesis: Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Collapse
MCT4 (SLC16A7) to provide energy substrates for neighboring motor neurons
Read more → - Warburg Astrocytes
MCT4) for lactate export ([Pellerin & Magistretti, 1994](https://doi.org/10.1073/pnas.91.22.10625)).
Read more →
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Related hypotheses
- AQP4 Autoantibodies in NMOSD Cause Bystander Oligodendrocyte Injury via Metabolic Coupling Disruption
claim that modulating AQP4; SLC16A1 (MCT1); SLC16A3 (MCT4) within the disease context of neurodegeneration ... claim that modulating AQP4; SLC16A1 (MCT1); SLC16A3 (MCT4) within th…
- Astrocyte-Neuron Metabolic Coupling Failure Precedes Neurodegeneration in FTD-GRN
specifically impairs expression of monocarboxylate transporter 4 (MCT4, encoded by SLC16A3) in astrocytes, which ... delivering astrocyte-derived lactate to neurons. MCT4 function…
- Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupling
monocarboxylate transporters: MCT1 (SLC16A1) and MCT4 (SLC16A3), which have distinct kinetic properties optimized for different ... perisynaptic space for neuronal uptake via MCT2…
- Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Collapse
glycolysis, exporting it via MCT1 (SLC16A1) and MCT4 (SLC16A7) to provide energy substrates for neighboring
- The Glial Ketone Metabolic Shunt Hypothesis
exported via monocarboxylate transporters MCT1 and MCT4 and imported by neurons through MCT2, where lactate