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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- mTOR Signaling in Neurodegeneration
mTOR[@zoncu2011]. ### mTORC2 (mTOR Complex 2) **Core components:** - **mTOR**: Catalytic
Read more → - MTOR Gene
MTOR"] -->|"data in"| MTOR["MTOR"] AKT["AKT"] -.->|"inhibits"| MTOR["MTOR
Read more → - mTOR Signaling in Autophagy and Lysosomal Function
mTOR-TFEB axis - Store-operated calcium entry (SOCE) affects mTOR
Read more → - mTOR Signaling Dysregulation in Progressive Supranuclear Palsy
mTOR Pathway in Normal Neuronal Function ### mTOR Complexes mTOR exists
Read more → - mTOR Signaling Dysregulation in Progressive Supranuclear Palsy
mTOR["mTOR"] PI3K["PI3K"] -.->|"downstream of"| mTOR["mTOR"] Sirolimus["Sirolimus
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Related hypotheses
- TREM2-mTOR Co-Agonism for Metabolic Reprogramming
Mechanistic Overview TREM2-mTOR Co-Agonism for Metabolic Reprogramming starts from the claim that modulating ... TREM2-mTOR pathway within the disease context of neurodegeneration…
- Disease-Associated Microglia Metabolic Reprogramming
Disease-Associated Microglia Metabolic Reprogramming via TREM2-mTOR Axis Modulation ## Introduction and Background Neurodegenerative diseases ... therapeutic development. ## Mol…
- Synergistic enhancement of autophagy and lysosomal biogenesis by combined mTOR inhibition and TFEB activation
autophagy and lysosomal biogenesis by combined mTOR inhibition and TFEB activation starts from the claim ... that modulating MTOR, TPCN2, TFEB within the disease context of neuros…
- APOE-Dependent Autophagy Restoration
receptor (LDLR) family, which activates PI3K-Akt-mTOR signaling more potently than APOE3 or APOE2 ... phagocytic functions. [PMID:41651180] ### Therapeutic Strategies 1. **mTOR …
- H4: Senomorphic Compounds Preserve Astrocyte Function While Reversing Senescence
Senescence starts from the claim that modulating MTOR; MEGF10; MERTK within the disease context ... Senescence starts from the claim that modulating MTOR; MEGF10; MERTK within the…