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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- POU5F1 (Oct4) - POU Class 5 Homeobox 1
OCT4) ## Overview POU5F1 (also known as OCT4 or OCT3/4) is a key transcription
Read more → - SOX2
OCT4["OCT4"] -->|"regulates"| SOX2["SOX2"] CANCER["CANCER"] -->|"therapeutic target"| SOX2
Read more → - KLF4 Gene
OCT4["OCT4"] -->|"regulates"| KLF4["KLF4"] PI3K["PI3K"] -->|"therapeutic target"| KLF4
Read more → - Sox2 Neurons
OCT4, SOX2, KLF4, c-MYC) capable of inducing pluripotency in somatic
Read more → - TET3 Gene
OCT4["OCT4"] -->|"activates"| TET3["TET3"] TET1["TET1"] -->|"activates"| TET3["TET3
Read more →
Graph neighborhood (5 nodes · 6 edges)
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Related hypotheses
- Partial Neuronal Reprogramming via Modified Yamanaka Cocktail
Cocktail starts from the claim that modulating OCT4 within the disease context of neurodegeneration ... Mechanism of Action: The central mechanism involves OCT4-mediated chromatin…
- Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigenetic Age and Restores Visual Function in Aged Retinal Neurons
Molecular Mechanism and Rationale The Yamanaka factors OCT4 (POU5F1), SOX2, KLF4 ... these marks without erasing cell-type identity. **OCT4** (POU5F1, POU domain, class 5, transcr…
- Partial OSK Reprogramming Reverses Epigenetic Aging Without Dedifferentiation
controlled expression of three Yamanaka factors—Oct4 (POU5F1), Sox2, and Klf4—to induce epigenetic rejuvenation ... methylation patterns without triggering complete cellular dedif…
- CyclinD1-Tagged Partial Cellular Reprogramming via Modified Yamanaka Cocktail Reverses Neuronal Senescence Without Compromising Cell Identity or Augmenting Tumor Risk
Full cellular reprogramming using the Yamanaka factors (OCT4, SOX2, KLF4, c-MYC; OSKM) converts differentiated ... expressed genes without inducing pluripotency markers (NANOG, OC…
- Metabolic Reprogramming to Reverse Senescence
fibroblasts can be rejuvenated through expression of OCT4, MYC, SOX2, and KLF4 (OSKM) factors ... lines of evidence. Partial reprogramming using OSKM (OCT4, SOX2, KLF4, MYC) facto…