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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- p62/SQSTM1
p62/SQSTM1 ## Introduction p62/SQSTM1 **Gene** [sqstm1](/genes/sqstm1) **UniProt ID** [Q13501](https://www.uniprot.org
Read more → - p62/SQSTM1 (Sequestosome-1)
p62/SQSTM1"] NEMO["NEMO"] -->|"co localizes"| p62_SQSTM1["p62/SQSTM1"] LC3["LC3"] -->|"interacts
Read more → - Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases
p62/SQSTM1**: Sequestration into aggregates unavailable for autophagy ### Stage 3: Cargo
Read more → - AUTOTAC: Autophagy-Targeting Chimera for Neurodegeneration
p62/SQSTM1, enabling selective autophagic degradation of otherwise "undruggable" targets implicated
Read more → - autophagy-lysosome-dysfunction
p62/SQSTM1, NBR1, OPTN, NDP52"] G --> H["Autophagosome Closure"] H --> I["Retrograde
Read more →
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Related hypotheses
- Autophagic Receptor Sequestration via K63-Ub 'Signalone' Recognition
specifically recognized by autophagy receptors including p62/SQSTM1 (sequestosome 1), OPTN (optineurin), and NDP52 (nuclear ... degradation. The UBA domain of p62/SQSTM1 exhibits …
- C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Granules
with the ubiquitin-associated (UBA) domains of p62/SQSTM1 (sequestosome 1) and OPTN (optineurin), two essential ... cellular quality control response. Under normal conditions, p62…
- mTORC1 Reactivation as Autophagy-Senescence Divergence Point Marker
aging disrupts autophagy-lysosome flux, leading to p62/SQSTM1 aggregation, DDR activation via ATM/ATR, and stabilization ... senescence through metabolic reprogramming. [PMID:3292…
- hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for miR-6361 Sequestration
turnover assays and accumulated higher levels of p62/SQSTM1 aggregates (1.9-fold increase). Caenorhabditis elegans studies ... increase 2.1-fold in treated mice, while p62/SQSTM1…
- Autophagosome Maturation Checkpoint Control
importantly, CSF measurements of LC3-II and p62/SQSTM1 provide functional readouts of autophagic flux, with ... serving as enrollment criteria. Patients demonstrating elevated p62…