No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- PARP1 (Poly(ADP-Ribose) Polymerase 1)
PARP1["PARP1"] USP1["USP1"] -->|"regulates"| PARP1["PARP1"] USP1["USP1"] -->|"binds
Read more → - PARP1 Gene
PARP1["PARP1"] USP1["USP1"] -->|"regulates"| PARP1["PARP1"] USP1["USP1"] -->|"binds
Read more → - Parthanatos in Neurodegeneration
PARP1 Overactivation"] B1["PARP1 Binds DNA Breaks"] B2["Excessive PAR Synthesis
Read more → - PARP in Neurodegeneration
PARP1 Activation"] B1["PARP1 Binds DNA Breaks"] B2["Excessive PAR Synthesis
Read more → - PARP1 Protein
PARP1 - [Tau](/proteins/tau) pathology affects PARP1 expression - PARP1-SIRT1 axis
Read more →
Graph neighborhood (30 nodes · 90 edges)
Click a neighbor to navigate · double-click opens in a new tab · open in full graph viewer
Related hypotheses
- PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Subsequent p53 Activation
Mechanistic Overview PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Subsequent p53 Activation starts ... from the claim that modulating PARP1 within the disease context…
- PARP1 Inhibition Therapy
Mechanistic Overview PARP1 Inhibition Therapy starts from the claim that modulating PARP1 within the disease ... cytoplasmic-toxicity. Poly(ADP-ribose) polymerase 1 (PARP1) repres…
- Oligodendrocyte DNA Repair Enhancement Therapy
Therapy starts from the claim that modulating PARP1 and XRCC1 within the disease context ... Therapy starts from the claim that modulating PARP1 and XRCC1 within the disease conte…
- Mitochondrial Dysfunction Increasing Neuronal Vulnerability to TDP-43 Toxicity
claim that modulating MCU, CK1D, CSNK2A1, GSK3B, PARP1 within the disease context of neurodegeneration ... claim that modulating MCU, CK1D, CSNK2A1, GSK3B, PARP1 within the diseas…
- DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed-Forward Loop
Loop starts from the claim that modulating PARP1, ATM, XRCC1, LIG3 within the disease context ... Loop starts from the claim that modulating PARP1, ATM, XRCC1, LIG3 within the dis…