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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Validated Hypothesis: SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence
PGC1α transcriptional activity. This deacetylation event activates PGC1α's coactivator
Read more → - TFEC Gene
PGC1α, PPARα Immune response TREM2, CD68, CX3CR1 Feature TFEC Primary
Read more → - TFEB Protein (Transcription Factor EB)
PGC1α Mitochondrial-Lysosomal Decou... The Mitochondrial-Lysosomal Metabolic Co... KG Connections
Read more → - TFEB Protein
PGC1α Mitochondrial-Lysosomal Decou... The Mitochondrial-Lysosomal Metabolic Co... KG Connections
Read more → - Composite Claim: TREM2 Links Microglial Lipid Sensing to Senescent Inflammatory State Transitions
PGC1α nutrient-sensing circuit in TREM2+ microglia) 2. [h-var-66156774e7
Read more →
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Related hypotheses
- PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Deficit to Restore Gamma Oscillations
Mechanistic Overview PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Deficit to Restore Gamma Oscillations starts ... process. The original description reads: "## Mechanis…
- TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Mechanistic Overview TFEB-PGC1α Mitochondrial-Lysosomal Decoupling starts from the claim that modulating TFEB within ... proliferator-activated receptor gamma coactivator 1-alpha …
- Theta-Gamma Coupling Modulates lncRNA-9969-Mediated Mitochondrial Biogenesis Through SST Interneuron-Specific ceRNA Networks
that modulating SST, CREB1, NRF1, lncRNA-9969, PGC1α, TFAM within the disease context of molecular ... that modulating SST, CREB1, NRF1, lncRNA-9969, PGC1α, TFAM within the diseas…
- Alpha-Beta Oscillation Entrainment Enhances lncRNA-9969-Mediated Mitochondrial Biogenesis Through SST Interneuron-Specific ceRNA Networks
claim that modulating SST, CREB1, lncRNA-9969, PGC1α, TFAM, NRF1 within the disease context ... claim that modulating SST, CREB1, lncRNA-9969, PGC1α, TFAM, NRF1 within the disease…
- SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence
through deacetylation of key transcriptional regulators including PGC1α, p53, and FOXO transcription factors. During aging ... begins with SIRT1's direct deacetylation of PGC1α at…