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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- EGLN1 — Egl-9 Family Prolyl Hydroxylase 1
PHD2 #### Amyloid-beta Effects - Aβ inhibits PHD2 function - Disrupts oxygen
Read more → - Parkinson's Disease HIF/Hypoxia Signaling Therapy Companies
PHD2 vs. PHD3). Different isoforms may have distinct roles in neuronal
Read more → - Hypoxia Response Pathway
PHD2, and PHD3) have distinct cellular distributions and functions[@appelhoff2004
Read more → - PHF6 Gene
PHD2: C-terminal PHD domain with similar function - **N-terminal
Read more → - HIF1AN — Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor
PHD2 | HIF-1α Pro402 | Primary oxygen sensor | | PHD3 | HIF-1α Pro564
Read more →
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Related hypotheses
- EPO Set Point Calibration Hypothesis
prolyl hydroxylase domain (PHD) system, where PHD2 (EGLN1) serves as the key oxygen sensor. Under ... normoxic conditions with adequate hematocrit, PHD2 hydroxylates HIF-1α and HI…
- Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift
Ser797, while simultaneously phosphorylating and inhibiting EGLN1 (PHD2, prolyl hydroxylase domain-containing protein ... Ser125. Under normoxic conditions, PHD2 normally hydroxyl…
- HIF1A stabilization lowers the activation threshold of circadian-disrupted microglia
involving prolyl hydroxylase domain proteins (PHDs), particularly PHD2 (EGLN1). These enzymes hydroxylate specific proline residues