No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- PICALM — Phosphatidylinositol Binding Clathrin Assembly Protein
PICALM CLU --"associated with"--> PICALM CR1 --"associated with"--> PICALM PICALM
Read more → - PICALM→Clathrin-Mediated Endocytosis→Aβ Accumulation→AD Causal Chain
PICALM Risk Variants → Clathrin-Mediated Endocytosis Dysfunction ### PICALM Protein Structure
Read more → - PICALM Protein
PICALM Protein ## Overview PICALM (Phosphatidylinositol Clathrin Assembly Lymphoid-myeloid leukemia
Read more → - Gene-Mechanism-Therapy Causal Chains
PICALM Expression Change"] K -->|"Lower expression risk"| C L["PICALM
Read more → - SORL1 Protein
PICALM["PICALM"] SORL1 -->|"associated with"| PICALM Ms["Ms"] SORL1 -->|"associated
Read more →
Graph neighborhood (30 nodes · 129 edges)
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Related hypotheses
- Tau-trafficking GWAS loci define a druggable PTK2B endocytosis-kinase axis in AD
PTK2B, BIN1, PICALM, and SORL1 form a trafficking and kinase-linked AD risk cluster ... because PTK2B is a kinase, BIN1 and PICALM implicate endocytosis, and SORL1 ties the module
- Endosomal trafficking defects are the common upstream lesion linking APP processing and cholinergic degeneration
AD-risk trafficking defects in
- Temporal order is subtype-specific rather than universal
The most defensible synthesis is