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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- MCOLN1 — Mucolipin-1 (TRPML1)
PIKFYVE["PIKFYVE"] PIKFYVE -->|"regulates"| MCOLN1 h_8ef34c4c -->|"targets gene"| MCOLN1
Read more → - ELAVL4 Gene
PIKFYVE["PIKFYVE"] style ELAVL4 fill:#4fc3f7,stroke:#333,color:#000 ``` **ELAVL4
Read more → - FIG4 Protein
PIKFYVE-associated protein) serves as the primary interacting partner, recruiting
Read more → - RNF20
PIKFYVE["PIKFYVE"] -->|"activates"| RNF20["RNF20"] RNA["RNA"] -->|"activates"| RNF20["RNF20
Read more → - FIG4 — FIG4 Phosphatase Homolog
PIKFYVE - **PIKFYVE** - phosphorylates PI3P to generate PI(3,5)P2 - **FYCO1
Read more →
Graph neighborhood (6 nodes · 7 edges)
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Related hypotheses
- PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5)P2→TRPML1→Calcineurin→TFEB Cascade in ALS Motor Neurons
Mechanistic Overview PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5)P2→TRPML1→Calcineurin→TFEB ... process. The original description reads: "## Mechanistic Overview …
- C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by PIKFYVE Inhibition via Lysosomal Exocytosis Restoration
Complex Dysfunction in C9-ALS Rescued by PIKFYVE Inhibition via Lysosomal Exocytosis Restoration starts from ... Complex Dysfunction in C9-ALS Rescued by PIKFYVE Inhibition via Ly…
- TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis
causes lysosomal storage and neurodegeneration 3. PIKFYVE inhibition activates MCOLN1-mediated lysosomal exocytosis, clearing alpha ... causes lysosomal storage and neurodegenerat…
- Glycine-Rich Domain Competitive Inhibition
models of motoneuron degeneration. [PMID:30335591]. 3. PIKFYVE inhibition mitigates disease in models of diverse
- Sequential TRPML1 Activation Following Autophagy Priming
causes lysosomal storage and neurodegeneration 3. PIKFYVE inhibition activates MCOLN1-mediated lysosomal exocytosis, clearing alpha
Related debates
- How does PIKFYVE inhibition activate unconventional protein clearance via exocytosis?
abstract describes a novel mechanism where PIKFYVE inhibition triggers exocytosis of aggregation-prone proteins ... approach. Gap type: unexplained_observation Source paper: PIKF…