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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- SLC7A11 Gene - xCT Cystine/Glutamate Antiporter
SLC7A11 FOXK2 -->|"regulates"| SLC7A11 SLC7A11 -->|"therapeutic_target"| ALS SLC7A11 -->|"therapeutic
Read more → - Validated Hypothesis: SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis After Cardiac Arrest
SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent
Read more → - xCT Protein - SLC7A11 Cystine/Glutamate Antiporter
SLC7A11 -.->|"inhibits"| ferroptosis SLC7A11 -.->|"inhibits"| ROS SLC7A11 -->|"regulates"| GPX4 SLC7A11
Read more → - GPX4 Gene - Glutathione Peroxidase 4
SLC7A11["SLC7A11"] -->|"activates"| GPX4["GPX4"] SLC7A11["SLC7A11"] -.->|"inhibits"| GPX4["GPX4
Read more → - Ferroptosis in Alzheimer's Disease
SLC7A11["SLC7A11"] -.->|"inhibits"| ferroptosis["ferroptosis"] MTOR["MTOR"] -->|"regulates"| ferroptosis["ferroptosis
Read more →
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Related hypotheses
- SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis After Cardiac Arrest
Mechanistic Overview SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal ... Arrest starts from the claim that modulating SLC7A11 (system Xc-) …
- Senescence-Induced Lipid Peroxidation Spreading
neurodegeneration markers. RNA interference targeting the worm SLC7A11 homolog exacerbates age-related neurodegeneration, while overexpression ... Ferroptosis Block"] --> K["GPX4 …
- Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Cell-Autonomous Glutamate Toxicity
transporter, composed of the light chain xCT (SLC7A11) and the heavy chain 4F2hc (SLC3A2), represents ... context of ALS pathophysiology, microglial SLC7A11 expression creates a p…
- Endothelial NRF2 Activation as a Master Switch for Post-CA BBB Protection
lipid peroxidation. Second, the cystine/glutamate antiporter SLC7A11 (system xc-) is upregulated, facilitating the import ... multiple neurodegenerative diseases, making the NRF2-…
- Ferroptosis Inhibition for α-Synuclein Neuroprotection
system Xc- cystine/glutamate antiporter (composed of SLC7A11 and SLC3A2 subunits) imports cystine for glutathione synthesis ... through multiple mechanisms, including transcriptio…