No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- SQSTM1 — Sequestosome 1 (p62)
SQSTM1_gene -->|"encodes"| SQSTM1_protein SQSTM1_protein -->|"activates"| NFE2L2 SQSTM1
Read more → - p62/SQSTM1 (Sequestosome-1)
SQSTM1["SQSTM1"] -->|"activates"| Tumor["Tumor"] SQSTM1["SQSTM1"] -->|"activates"| Als["Als"] SQSTM1
Read more → - SQSTM1 Protein (p62/Sequestosome-1)
SQSTM1["SQSTM1"] MITOPHAGY["MITOPHAGY"] -->|"activates"| SQSTM1["SQSTM1"] PARKINSON_S_DISEASE
Read more → - p62/SQSTM1
SQSTM1["P62/SQSTM1"] -->|"co discussed"| SQSTM1["SQSTM1"] P62_SQSTM1["P62/SQSTM1"] -->|"co discussed
Read more → - SQSTM1/p62 Protein
SQSTM1 -->|"regulates"| Cancer SQSTM1 -->|"activates"| Autophagy SQSTM1 -->|"activates"| Tumor SQSTM1
Read more →
Graph neighborhood (30 nodes · 259 edges)
Click a neighbor to navigate · double-click opens in a new tab · open in full graph viewer
Related hypotheses
- p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle Cargo for Coordinated Autophagy
starts from the claim that modulating SQSTM1/p62 (SQSTM1), ULK1/FIP200 within the disease context of neurodegeneration ... starts from the claim that modulating SQSTM1/p62 (SQSTM1…
- Lamin B1 Degradation as Irreversibility Gate
claim that modulating LMNB1, LMNB2, NCOA4, SQSTM1 within the disease context of molecular biology ... claim that modulating LMNB1, LMNB2, NCOA4, SQSTM1 within the disease context …
- Liquid-Liquid Phase Separation (LLPS) Saturation Partitioning Excludes Autophagy Receptors from SG Core
more available. Skeptic identifies critical flaw: SQSTM1 and CALCOCO2 have multivalent domains predicted to partition ... high-level therapeutic assertion. 2. SQSTM1 undergoes LLP…
- TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gradient via K63-Linked Chain Accumulation
preventing chain propagation in the dense core. SQSTM1 and CALCOCO2 engage these peripheral chains ... high-level therapeutic assertion. 2. SQSTM1 recognizes K63-Ub chains on SG s…
- Kinesin-Dependent Peripheral Microtubule Transport Maintains Receptor Exclusion from SG Core
arrested state, cannot engage motor-driven peripheralization. SQSTM1's LC8 dimer binding motifs and CALCOCO2 ... transports stress granules. [PMID:25358400]. 2. SQSTM1 interaction…