No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- SQSTM1/p62
SQSTM1/p62"] -->|"inhibits"| MAPK_ERK["MAPK/ERK"] SQSTM1_p62["SQSTM1/p62"] -->|"interacts with
Read more → - TBK1-Mediated Neuroinflammation Hypothesis — Autophagy Failure and Innate Immune Dysregulation in FTD/ALS
SQSTM1/p62) and innate immune signaling (through activation of STING and IRF3
Read more → - SQSTM1/p62 Protein
SQSTM1/p62 Protein ## Overview SQSTM1/p62 Protein Symbol SQSTM1 Full Name SQSTM1/p62
Read more → - SQSTM1 — Sequestosome 1 (p62)
SQSTM1/p62 Protein"] NFE2L2["NFE2L2/Nrf2 Transcription Factor"] autophagy["Autophagy Process"] mitophagy
Read more → - TBK1 Autophagy and Neuroinflammation ALS/FTD Causal Chain
SQSTM1/p62](/genes/sqstm1) pages. ## The Causal Chain ```mermaid flowchart TD subgraph
Read more →
Graph neighborhood (5 nodes · 5 edges)
Click a neighbor to navigate · double-click opens in a new tab · open in full graph viewer
Related hypotheses
- GATA4 Stabilization and NF-κB Co-activation Identifies Senescent Microglia
starts from the claim that modulating GATA4, SQSTM1/p62, NFKB subunits within the disease context ... starts from the claim that modulating GATA4, SQSTM1/p62, NFKB subunits within…
- p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle Cargo for Coordinated Autophagy
Autophagy starts from the claim that modulating SQSTM1/p62 (SQSTM1), ULK1/FIP200 within the disease context ... Autophagy starts from the claim that modulating SQSTM1/p62 (SQSTM1)…
- Autophagic Flux Enhancement Synergizes With Chaperones to Clear High-Molecular-Weight Tau Seeds
membrane protein 2A (LAMP2A), and sequestosome 1 (SQSTM1/p62), creating a synergistic clearance system that targets ... disaggregated oligomeric species generated by chaperone act…
- Transcriptional Autophagy-Lysosome Coupling
genes including ATG5, ATG7, ATG12, LC3B, BECN1, SQSTM1/p62, ULK1 - Increases autophagosome formation and autophagy flux ... activate genes with hybrid promoters (e.g., SQSTM1/p62 …
- TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis
compensatorily. TFEB augmentation could bypass TBK1 deficiency. - **SQSTM1/p62** (sequestosome 1): An autophagy receptor that directly