No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- SREBF1 Gene
SREBP1c | SREBF1 | Insulin-regulated isoform | Liver, adipose, brain | The SREBP1
Read more → - FAS Protein
SREBP1C["SREBP1C"] -->|"upregulates"| FAS["FAS"] FOXO["FOXO"] -->|"activates"| FAS["FAS"] APOPTOSIS
Read more → - FAS Gene
SREBP1C["SREBP1C"] -->|"upregulates"| FAS["FAS"] FOXO["FOXO"] -->|"activates"| FAS["FAS"] APOPTOSIS
Read more → - SREBP1 Protein
SREBP1c**, generated by alternative promoter usage. SREBP1 is synthesized as an inactive
Read more → - Liver X Receptor (LXR) Signaling in Neurodegeneration
SREBP1c) - Inflammation (MMP-9, COX-2) - Neuroprotection (BDNF, GDNF)[@zhou2020
Read more →
Graph neighborhood (7 nodes · 8 edges)
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Related hypotheses
- APOE4 drives astrocyte metabolic reprogramming toward glycolysis via PGC-1α suppression, reducing fatty acid oxidation and promoting lipogenesis that feeds pathological lipid droplet formation
stearic acid (C18:0), consistent with upregulated SREBP1c-mediated lipogenesis. In vitro experiments using primary ... restoring mitochondrial biogenesis programs. Complementary…
- H3: APOE4 Impairs Cholesterol Trafficking, Triggering Astrocyte Senescence
fold selectivity for ABCA1 induction versus SREBP1c activation, potentially offering improved therapeutic windows. Gene therapy
- SASP Modulation Rather Than Cell Elimination
cancer. [PMID:40513577]. 2. PubMed search found: SREBP1c-PARP1 axis tunes anti-senescence activity