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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Validated Hypothesis: SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis After Cardiac Arrest
system Xc-) and GPX4](https://www.ncbi.nlm.nih.gov/gene/?term=SLC7A11 (system Xc-) and GPX4
Read more → - Ferroptotic Neurons
System Xc- (SLC7A11/SLC3A2) Complex The cystine/glutamate antiporter system Xc- is critical
Read more → - PSP Ferroptosis and Iron-Dependent Cell Death
SYSTEM_XC["System Xc⁻ Inhibition (Cystine/Glutamate Antiporter)"] SYSTEM_XC -->|reduces
Read more → - Ferroptosis Therapy for Parkinson's Disease
System Xc- (Cystine/Glutamate Antiporter) The [System Xc-](/proteins/slc7a11-protein) (SLC7A11) is the cystine/glutamate
Read more → - Ferroptosis in Parkinson's Disease
System Xc- (Cystine/Glutamate Antiporter) The system Xc- transporter (composed of SLC7A11
Read more →
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Related hypotheses
- SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis After Cardiac Arrest
from the claim that modulating SLC7A11 (system Xc-) and GPX4 within the disease context ... from the claim that modulating SLC7A11 (system Xc-) and GPX4 within the disease context
- Ferroptosis as Primary Driver of Motor Neuron Death
depleted (by erastin/IKE inhibition of system Xc-), lipid peroxides accumulate beyond a lethal threshold. **Iron ... matched controls. The role of system Xc- ( SLC7A11) is equally…
- Ferroptosis Inhibition for α-Synuclein Neuroprotection
permissive environment for ferroptosis execution. The system Xc- cystine/glutamate antiporter (composed of SLC7A11 and SLC3A2 ... representing a critical vulnerability point. When…
- Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Cell-Autonomous Glutamate Toxicity
Molecular Mechanism and Rationale** The system xc- transporter, composed of the light chain xCT (SLC7A11 ... that pathological microglial states preferentially utilize system xc-…
- Ferroptosis as Context-Dependent and Motor Neuron-Subtype Selective
disease. 2. **Sulfasalazine (NCT00353678)**: This system Xc- inhibitor accelerated disease progression, which is consistent with ... outcomes in some subgroups. Ceftriaxone upregu…
Related debates
- Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron chelation therapies
GPX4 (glutathione peroxidase 4), lipid peroxidation, system Xc- cystine/glutamate antiporter, and iron chelation therapies