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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- MCOLN1 — Mucolipin-1 (TRPML1)
TRPML1["TRPML1"] MCOLN1 -->|"encodes"| TRPML1 Mucolipidosis_Type_IV["Mucolipidosis Type
Read more → - Mucolipin-1 (TRPML1) Protein
TRPML1) Protein | | | |---|---| | **Protein Name** | Mucolipin-1 (TRPML1) | | **Gene** | [MCOLN1](/genes/mcoln1
Read more → - Lysosomal Calcium Dysregulation in Neurodegeneration
TRPML1 dysfunction:** Aβ accumulation impairs TRPML1-mediated lysosomal calcium release
Read more → - Lysoway Therapeutics
TRPML1 Agonists **TRPML1** (also known as MCOLN1) is a lysosomal
Read more → - Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease
TRPML1** (transient receptor potential mucolipin 1) on lysosomes - **VDAC1** (voltage
Read more →
Graph neighborhood (16 nodes · 19 edges)
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Related hypotheses
- Sequential TRPML1 Activation Following Autophagy Priming
Mechanistic Overview Sequential TRPML1 Activation Following Autophagy Priming starts from the claim that modulating MCOLN1 ... TRPML1), ATG7 within the disease context of neurodeg…
- Lysosomal Calcium Channel Modulation Therapy
Rationale** The transient receptor potential mucolipin 1 (TRPML1) channel, encoded by the MCOLN1 gene, represents ... membrane trafficking dynamics within neuronal cells. TRPML1 f…
- Spatiotemporal coupling between TRPML1-mediated lysosomal calcium release and calcineurin nanodomain activation
Mechanism and Rationale** The spatiotemporal coupling between TRPML1-mediated lysosomal calcium release and calcineurin nanodomain ... precise orchestration of intracellular calc…
- PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5)P2→TRPML1→Calcineurin→TFEB Cascade in ALS Motor Neurons
Aggregate Exocytosis via PI(3,5)P2→TRPML1→Calcineurin→TFEB Cascade in ALS Motor Neurons ... Aggregate Exocytosis via PI(3,5)P2→TRPML1→Calcineurin→TFEB Cascade in ALS Motor Neurons
- TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis
Mechanistic Overview TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis starts from the claim ... process. The original description reads: "## Mechanistic Ov…
Related debates
- Does TRPML1 enhancement cause therapeutic benefit or paradoxical lysosomal dysfunction in vivo?
debate revealed conflicting evidence about whether TRPML1 activation rescues or worsens lysosomal function, with studies