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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Blood-Brain Barrier Dysfunction Pathway
ZO-1) - **[Pericytes](/cell-types/pericytes)** (~80% coverage, critical for BBB integrity
Read more → - Blood-Brain Barrier Breakdown in Neurodegeneration
ZO-1)"] TJ --> ED["Endothelial Dysfunction"] ED --> BP["Barrier Permeability
Read more → - Neurovascular Unit Dysfunction Hypothesis in Parkinson's Disease
ZO-1) in PD brains[@gomez2022bba] - **Neuroimaging studies** using dynamic
Read more → - CING1 Gene
ZO-1 | Direct binding | Cytoskeletal linkage | | Actin | Indirect | Cell骨架 connection
Read more → - blood-brain-barrier-endothelial-cells
ZO-1, ZO-2, and ZO-3, anchoring the junction
Read more →
Graph neighborhood (12 nodes · 13 edges)
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Related hypotheses
- Focused Ultrasound with Microbubble Contrast Agents for Antibody CNS Delivery
CLDN5) and zonula occludens-1 (ZO-1) proteins, which create impermeable paracellular seals preventing molecular ... interactions between adjacent endothelial cells, while ZO-1 ser…
- Piezoelectric Nanochannel BBB Disruption
through interactions with zonula occludens proteins (ZO-1, ZO-2, ZO-3) and the actin ... dependence on endothelial-specific transcription factors (ZO-1, occludin interactions) - *…
- Endothelial NRF2 Activation as a Master Switch for Post-CA BBB Protection
occludin, and zonula occludens-1 (ZO-1) through both direct transcriptional mechanisms and indirect effects ... peroxidation (4-HNE accumulation) correlating with ZO-1/occludin de…
- Leaky Gut LPS Translocation Activates Systemic TLR4/MyD88 Signaling, Driving CNS Monocyte Infiltration
intestinal tight junctions (occludin, claudin-1, ZO-1) and reduces α-defensin production, permitting Gram
- Dual-Receptor Antibody Shuttling
proteins including claudin-5, occludin, and ZO-1. This architecture restricts paracellular diffusion while receptor ... claudin-5), **OCLN** (occludin), and **TJP1** (ZO-1)—exhibi…