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Wiki pages (3)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- MITF Gene — Microphthalmia-Associated Transcription Factor
ATP6V1A**: V-ATPase proton pump (lysosomal acidification) - **GLB1** (beta-galactosidase
Read more → - LAMTOR1 - Late Endosomal/Lysosomal Adaptor 1
ATP6V1A["ATP6V1A"] -->|"co associated with"| LAMTOR1["LAMTOR1"] style h_e3a48208
Read more → - Validated Hypothesis: APOE-Dependent Autophagy Restoration
ATP6V1A (reduced 0.8x) in APOE4 carriers - Autophagy initiation: ULK1
Read more →
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Related hypotheses
- Restoration of V-ATPase function reverses lysosomal acidification defect in AD neurons
neurons starts from the claim that modulating ATP6V1A, ATP6V0C within the disease context of neuroscience ... neurons starts from the claim that modulating ATP6V1A, ATP6V0C within…
- Lysosomal pH Restoration Upstream of TFEB
TFEB starts from the claim that modulating ATP6V1A within the disease context of neurodegeneration ... TFEB starts from the claim that modulating ATP6V1A within the disease contex…
- APOE-Dependent Autophagy Restoration
reduced 0.7x), CTSD (reduced 0.6x), ATP6V1A (reduced 0.8x) in APOE4 carriers - Autophagy
- Spatiotemporal coupling between TRPML1-mediated lysosomal calcium release and calcineurin nanodomain activation
fold increases), ATP6V1A (lysosomal V-ATPase subunit), and LAMP1, indicating enhanced lysosomal biogenesis persisting weeks
- Temporal Microglial State Switching
dysfunctional — lysosomal acidification fails (due to reduced Atp6v1a expression), phagocytosed Aβ accumulates in lysosomes without