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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- JAK-STAT Signaling Pathway in Neurodegeneration
JAK["JAK"] STAT3["STAT3"] -->|"therapeutic target"| JAK["JAK"] ALZHEIMER_S_DISEASE
Read more → - JAK-STAT and Cytokine Signaling in 4R-Tauopathies
JAK["JAK"] STAT3["STAT3"] -->|"therapeutic target"| JAK["JAK"] ALZHEIMER_S_DISEASE
Read more → - JAK-STAT Signaling in Parkinson's Disease
JAK["JAK"] STAT3["STAT3"] -->|"therapeutic target"| JAK["JAK"] ALZHEIMER_S_DISEASE
Read more → - JAK-STAT Signaling Pathway in Neurodegeneration
JAK["JAK"] STAT3["STAT3"] -->|"therapeutic target"| JAK["JAK"] ALZHEIMER_S_DISEASE
Read more → - JAK Inhibitors in Parkinson's Disease
JAK["JAK"] STAT3["STAT3"] -->|"therapeutic target"| JAK["JAK"] ALZHEIMER_S_DISEASE
Read more →
Graph neighborhood (4 nodes · 4 edges)
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Related hypotheses
- α4β1 Integrin (VLA-4) and JAK/STAT Pathway
flaw: integrins do not canonically signal via JAKs. JAK1/JAK2 are associated with cytokine receptors ... receptor). The connection from α4β1 to JAK is not established in any cell …
- H2: SASP Neutralization via JAK/STAT Inhibition Preserves Astrocyte Function
coverage (misses proteases, EVs, oxidized lipids) and JAK inhibitor effects on astrocyte-specific signaling. Framed ... causes neuronal tau phosphorylation. [PMID:28445112]. 2. JA…
- IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microglia Interface
triggers homodimerization and subsequent activation of the JAK-STAT signaling cascade, primarily involving JAK1, JAK2 ... /IL-6R complex activates gp130 signaling and downstream J…
- Restoring AQP4 Astrocyte Polarization Enhances Glymphatic Tau Clearance and Limits Template-Dependent Spreading
high-level therapeutic assertion. 3. JAK-STAT signaling linked to AQP4 dysregulation (identifier: 32451398). This ... with tau pathology burden. [PMID:32143252]. 3. JAK-STAT signa…
- GFAP-Positive Reactive Astrocyte Subtype Delineation
Astrocyte Reactivity Pathways" INJ["CNS Injury/Disease"] -->|"cytokines"| JAK["JAK/STAT3"] JAK -->|"transcription"| GFAP["GFAP Upregulation