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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Validated Hypothesis: Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Collapse
LDHA, PDHA1](https://www.ncbi.nlm.nih.gov/gene/?term=SLC16A1, SLC16A7, LDHA, PDHA1) - [UniProt: SLC16A1
Read more → - Immune Atlas: Neuroinflammation Analysis
LDHA is upregulated in AD microglia **Testable Prediction:** LDHA inhibition
Read more → - PDK3 - 3-Phosphoinositide-Dependent Protein Kinase-3
LDHA["LDHA"] -->|"activates"| PDK3["PDK3"] AND["AND"] -->|"activates"| PDK3["PDK3
Read more → - Lactate Lactylation in Neurodegeneration
LDHA["LDHA"] -->|"regulates"| lactate["lactate"] SIRT1["SIRT1"] -->|"modulates"| lactate["lactate
Read more → - SLC1A5 Gene
LDHA["LDHA"] -->|"activates"| SLC1A5["SLC1A5"] PKM2["PKM2"] -->|"activates"| SLC1A5["SLC1A5
Read more →
Graph neighborhood (3 nodes · 4 edges)
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Related hypotheses
- TREM2-APOE4 Axis Drives Metabolic Inflexibility in DAM
from the claim that modulating TREM2, APOE4, LDHA within the disease context of Alzheimer ... from the claim that modulating TREM2, APOE4, LDHA within the disease context of Alzhe…
- Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Collapse
several key regulatory nodes. Lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactate ... metabolic reprogramming cascade: HIF-1α directly upregulates LDHA …
- Dysregulated microglial glycolysis via HIF1α activation shifts the balance from neuroprotective surveillance to complement-mediated synapse engulfment
starts from the claim that modulating HIF1A, LDHA, LDHB, PKM2, TREM2, AMPK/mTOR within the disease ... starts from the claim that modulating HIF1A, LDHA, LDHB, PKM2, TREM2, AMPK/m…
- Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interface Biomarker
Biomarker starts from the claim that modulating LDHA, TREM2 within the disease context of translational ... Biomarker starts from the claim that modulating LDHA, TREM2 within the …
- Oligodendrocyte Progenitor Cell Metabolic Reprogramming
phosphofructo-2-kinase/fructose-2,6-biphosphatase 3), and LDHA (lactate dehydrogenase A). PDK1 serves ... energetic demands of myelin synthesis and maintenance. LDHA completes th…