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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- SLC16A1 — Solute Carrier Family 16 Member 1 (Monocarboxylate Transporter 1)
MCT1["MCT1 Transporter"] MCT1 --> Neuron["Neuron"] Neuron --> OxPhos["Oxidative Phosphorylation
Read more → - Metabolic Coupling and the Energy Substrate of Computation
MCT1 and MCT4 are expressed on astrocytes and on the vascular
Read more → - Oligodendrocytes
MCT1 Enhancers"] --> MP["Metabolic Support"] TH5["Iron Chelation"] --> NP["Neuroprotection
Read more → - Validated Hypothesis: Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Collapse
MCT1 (SLC16A1) and MCT4 (SLC16A7) to provide energy substrates for neighboring
Read more → - Disease-Associated Oligodendrocytes
MCT1 - **Pyruvate recycling**: Support mitochondrial function - **Glutamine synthesis**: Provide precursor
Read more →
Graph neighborhood (3 nodes · 3 edges)
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Related hypotheses
- SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-Dependent Axon Degeneration
Mediated NAD+ Depletion as Terminal Executor of MCT1-Dependent Axon Degeneration starts from the claim ... Mediated NAD⁺ Depletion as Terminal Executor of MCT1-Dependent Axon Dege…
- AQP4 Autoantibodies in NMOSD Cause Bystander Oligodendrocyte Injury via Metabolic Coupling Disruption
from the claim that modulating AQP4; SLC16A1 (MCT1); SLC16A3 (MCT4) within the disease context ... from the claim that modulating AQP4; SLC16A1 (MCT1); SLC16A3 (MCT4) within the d…
- Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupling
symbiosis depends critically on two monocarboxylate transporters: MCT1 (SLC16A1) and MCT4 (SLC16A3), which have distinct ... kinetic properties optimized for different metabolic r…
- Parvalbumin Interneuron Vulnerability Links Lactate Transport to Gamma Oscillation Dysfunction
into neurons via monocarboxylate transporters (MCTs), primarily MCT1 on astrocytes and MCT2 on neurons. Neuronal ... from the topology of this system. Astrocytic MCT1 expression a…
- Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker
specifically mediated through the monocarboxylate transporter 1 (MCT1) encoded by SLC16A1. This transporter serves ... local energy demands. The SLC16A1-encoded MCT1 transporter f…
Related debates
- What is the molecular mechanism by which oligodendroglial MCT1 disruption causes axon damage and neuron loss?
study shows that MCT1 disruption leads to axon degeneration and neuron death, but the specific