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Wiki pages (4)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- LXR Protein (Liver X Receptor)
NR1H2 Gene Variant Effect NR1H3 (LXRα) variants Altered activity NR1H2
Read more → - NR1H3 - Nuclear Receptor Subfamily 1 Group H Member 3
NR1H2) agonists for brain-specific effects - Understanding isoform-specific roles
Read more → - Liver X Receptor (LXR) Signaling in Neurodegeneration
NR1H2)** is ubiquitously expressed, including in neurons and glial cells
Read more → - LXR-alpha Protein
NR1H2) is also important for dopamine neuron survival ### Other Neurodegenerative
Read more →
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Related hypotheses
- LXRβ-Selective Agonism as a Precision Therapeutic for APOE4-Driven Myelin Deficits
Deficits starts from the claim that modulating NR1H2 (LXRβ) within the disease context of neurodegeneration ... distribute cholesterol for myelin sheath synthesis. LXRβ (NR1H2) se…
- LXRβ-Selective Agonism to Simultaneously Enhance APOE Lipidation and Reduce Microglial Cholesterol Accumulation
exploits the predominant CNS expression of LXRβ (NR1H2) to achieve therapeutic effects while potentially avoiding
- H3: APOE4 Impairs Cholesterol Trafficking, Triggering Astrocyte Senescence
molecules activate both LXRα (NR1H3) and LXRβ (NR1H2), inducing robust ABCA1 and ABCG1 transcription through
- Selective LXRβ agonists restore ABCA1/ABCG1 expression and APOE lipidation in APOE4 astrocytes, normalizing cholesterol export and reducing AD-relevant neurotoxicity
**Molecular Mechanism and Rationale** The
- Apolipoprotein E4-Mediated Metabolic Dysfunction Correction via Liver X Receptor Agonism
Apolipoprotein E4-Mediated Metabolic Dysfunction