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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Validated Hypothesis: Dual-Receptor Antibody Shuttling
TJP1** follow a near-identical vascular distribution, with **TJP1** showing
Read more → - CLDN5 — Claudin-5
TJP1["TJP1"] -->|"interacts with confi"| CLDN5["CLDN5"] OCLN["OCLN"] -->|"interacts
Read more → - Endothelial Cells
TJP1** - Zonula occludens-1 (ZO-1), scaffolding protein ### Angiogenesis Genes
Read more → - Brain Capillary Endothelial Cells
TJP1)**: Scaffolding protein that organizes junctional proteins to the actin
Read more → - Cerebral Endothelial Cells in Neurodegeneration
TJP1 (ZO-1), SLC2A1 (GLUT1) **Developmental Origin** Neuroectoderm (angioblasts) **Key Functions
Read more →
Graph neighborhood (2 nodes · 2 edges)
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Related hypotheses
- Intestinal Permeability Defects → Systemic LPS Translocation → Microglial Priming
that modulating Tight junction complex (CLDN1, OCLN, TJP1), LBP, CD14, TLR4, MYD88, NFKB1 within ... that modulating Tight junction complex (CLDN1, OCLN, TJP1), LBP, CD14, TLR4, M…
- Dual-Receptor Antibody Shuttling
CLDN5** (claudin-5), **OCLN** (occludin), and **TJP1** (ZO-1)—exhibits a highly compartmentalized expression pattern ... required to maintain barrier integrity. **OCLN** and **TJP…
- HTR2A-Mediated MMP-9 Suppression Preserves BBB Integrity at Low Doses
Trazodone's 5-HT2A antagonism
- Leaky Gut LPS Translocation Activates Systemic TLR4/MyD88 Signaling, Driving CNS Monocyte Infiltration
Dysbiosis compromises intestinal tight junctions
- Targeted Butyrate Supplementation for Microglial Phenotype Modulation
inflammatory pathway - Tight junction proteins (CLDN5, OCLN, TJP1) reduced in cerebrovascular cells of AD donors