{
"title": "Resolve: What evidence would resolve: TNFα scaling literature almost entirely uses homeostatic scaling paradigms in visual cortex; it is unclear whether astrocyte vs microglial TNF source shifts with brain region and activity sta",
"controls": "Define controls during protocol conversion.",
"irb_required": false,
"proposer_ref": "persona:persona-jerome-lecoq",
"review_ingest": {
"schema": "scidex-computational-review-package-ingest@v1",
"source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes/blob/1a55da0634a3bc04e5688792ed12141ce271d28e/evidence/section_08_evidence_package.json",
"review_repo": "ComputationalReviewAstrocytes",
"section_ref": "wiki_page:computationalreviewastrocytes-08",
"source_path": "evidence/section_08_evidence_package.json",
"source_review_proposal_ref": "experiment_proposal:exprop-6f20e100f84d"
},
"design_summary": "Cell-type-specific TNF conditional knockouts (GFAP-Cre vs Cx3cr1-CreER) in a common scaling paradigm across cortical regions and after inflammatory challenge.",
"hypothesis_ref": "open_question:oq-6acc16b151f6",
"generation_trigger": "from-gap",
"proposer_binding_id": "jerome-lecoq-gbo-neuroscience",
"sample_size_estimate": "To be estimated during protocol design."
}