Mechanistic pathways by which microbiome-based interventions influence neurodegenerative disease progression

PMID:41459056 reviewed that probiotics, prebiotics, synbiotics, and postbiotics can modulate the microbiota-gut-brain axis to influence AD, PD, MS, ALS, and HD. However, which specific microbial species, metabolites (SCFAs, bile acids, tryptophan derivatives), and gut-brain signaling pathways mediate observed neurological benefits is largely unknown. Clinical trial design remains empirical.

Resolved by hypothesis h-var-08a4d5c07a: Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration. Score: 0.907. Supporting PMIDs: 33875891, 30610225, 31748742, 27519954, 33741860.