Retinal microglia S100A9-mediated NLRP3 inflammasome activation as a systemic inflammation link to neurodegeneration

neurodegeneration resolved composite 64%
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Composite
64%
Novelty
75%
Mechanistic
—
Druggability
—
Priority
62%
Importance
65%
Tractability
60%
Market price
50%

Description

PMID:10.1101/2024.10.30.621160 identified retinal microglia-derived S100A9 activating NLRP3 inflammasome in obese pig retina. S100A9 is also elevated in AD brains. Whether retinal S100A9-NLRP3 signaling reflects or drives brain neurodegeneration, and whether the eye can serve as a window to CNS neuroinflammation via microglia-derived DAMPs is an unresolved mechanistic question.

Evidence summary

Resolved by hypothesis h-var-08a4d5c07a: Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration. Score: 0.907. Supporting PMIDs: 33875891, 30610225, 31748742, 27519954, 33741860.