How can pathological vs beneficial microglial populations be selectively targeted through TREM2 modulation?

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75%

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50%

Description

The debate proposed selective elimination of pathological microglia while preserving healthy populations, but no mechanism was identified to achieve this selectivity. This represents a critical therapeutic design challenge.

Source: Debate session sess_SDA-2026-04-10-trem2-ad (Analysis: trem2-ad)

Evidence summary

Resolved by hypothesis h-var-66156774e7: TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration. Score: 0.892. Supporting PMIDs: 37099634, 31932797, 36306735, 28802038, 41757182.

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