Description
The authors explicitly identify modeling resilience in animals as a major methodological challenge hampering progress. This limitation constrains mechanistic studies and therapeutic development since human studies alone cannot provide sufficient causal evidence.
Gap type: open_question Source paper: Neurobiology and systems biology of stress resilience. (None, None, PMID:38483288)
Evidence summary
Resolved by hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance. Score: 0.964. Supporting PMIDs: 19449329, 23431156, 26282667, 40994429, 40796363.