Description
The study shows rTMS targeting DLPFC reduces CPSP incidence, but the underlying neural pathways and brain network changes mediating this preventive effect remain unexplained. Understanding these mechanisms is crucial for optimizing stimulation protocols and identifying responder profiles.
Gap type: unexplained_observation Source paper: Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study. (2026, BMC Med, PMID:41943114)
Evidence summary
Resolved by hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance. Score: 0.964. Supporting PMIDs: 19449329, 23431156, 26282667, 40994429, 40796363.