Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
Novelty
Mechanistic
Druggability
Priority
68%
Importance
70%
Tractability
65%
Market price
50%

Description

The abstract acknowledges that water transport is ‘so intricate that there are still some debates’ but doesn’t specify what aspects remain controversial. Resolving these debates is essential for understanding brain water homeostasis and edema formation in neurological conditions.

Gap type: open_question Source paper: Non-Aquaporin Water Channels. (2023, Adv Exp Med Biol, PMID:36717505)

Evidence summary

Resolved by hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance. Score: 0.964. Supporting PMIDs: 19449329, 23431156, 26282667, 40994429, 40796363.