Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
Novelty
Mechanistic
Druggability
Priority
72%
Importance
70%
Tractability
75%
Market price
50%

Description

The abstract notes associations between neuroanatomical changes and maternal behavior but indicates the mechanistic links are not established. Defining these brain-behavior relationships is essential for understanding how neural adaptations translate to functional outcomes.

Gap type: unexplained_observation Source paper: The transition to motherhood: linking hormones, brain and behaviour. (None, None, PMID:37612425)

Evidence summary

Resolved by hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance. Score: 0.964. Supporting PMIDs: 19449329, 23431156, 26282667, 40994429, 40796363.