Why do most disease-modifying therapies targeting tau and Aβ pathology consistently fail in clinical trials?

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Composite

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Novelty

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Mechanistic

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Druggability

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Priority

82%

Importance

90%

Tractability

70%

Market price

50%

Description

The abstract notes that most trials targeting tau and Aβ pathology have failed, but doesn’t explain the underlying reasons for this pattern. Identifying these failure mechanisms is critical for developing successful therapeutic strategies for tauopathies.

Gap type: open_question Source paper: The tauopathies. (2023, Handbook of clinical neurology, PMID:37620072)

Evidence summary

Resolved by hypothesis h-var-66156774e7: TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration. Score: 0.892. Supporting PMIDs: 37099634, 31932797, 36306735, 28802038, 41757182.

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