Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
Novelty
Mechanistic
Druggability
Priority
78%
Importance
75%
Tractability
85%
Market price
50%

Description

The abstract shows that 35.55% of patients specifically hallucinate people and faces rather than other visual content, but doesn’t explain this bias. This selectivity suggests preferential involvement of face-processing networks that warrants investigation.

Gap type: unexplained_observation Source paper: [Charles Bonnet syndrome. A 45-case series]. (2015, Revista de neurologia, PMID:25857856)

Evidence summary

Resolved by hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance. Score: 0.964. Supporting PMIDs: 19449329, 23431156, 26282667, 40994429, 40796363.