Description
The abstract describes complex visual hallucinations (people, faces, movement) occurring specifically in cognitively intact patients with vision loss, but provides no mechanistic explanation. Understanding this phenomenon could reveal how visual cortex reorganizes after sensory deprivation and inform treatment approaches.
Gap type: unexplained_observation Source paper: [Charles Bonnet syndrome. A 45-case series]. (2015, Revista de neurologia, PMID:25857856)
Evidence summary
Resolved by hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance. Score: 0.964. Supporting PMIDs: 19449329, 23431156, 26282667, 40994429, 40796363.