How should GBA-PD patients be stratified for clinical trials to optimize therapeutic outcomes?

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Priority

76%

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82%

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Market price

50%

Description

The abstract mentions the need for patient stratification and cohort enrichment strategies but doesn’t specify the criteria or methods. This gap limits the design of effective clinical trials and may explain variable treatment responses in heterogeneous PD populations.

Gap type: open_question Source paper: GBA-associated PD: chances and obstacles for targeted treatment strategies. (2022, Journal of neural transmission (Vienna, Austria : 1996), PMID:35639160)

Evidence summary

Resolved by hypothesis h-f1c67177: Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of Microglial State Transition Restoration. Score: 0.887. Supporting PMIDs: 31257151, 37291336, STRING:0.685, 39002124, computational:ad_clinical_trial_failures.

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