Description
STOP is described as calmodulin-regulated but the specific regulatory mechanisms and how calmodulin modulates STOP’s microtubule-stabilizing activity remain unexplained. This gap limits understanding of calcium-dependent cytoskeletal regulation in neurons.
Gap type: unexplained_observation Source paper: STOP proteins. (1999, Cell structure and function, PMID:15218867)
Evidence summary
Resolved by hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance. Score: 0.964. Supporting PMIDs: 19449329, 23431156, 26282667, 40994429, 40796363.