Can TET2-mediated demethylation overcome established epigenetic memory in chronic neurodegeneration states?

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Description

The epigenetic hypothesis proposes reversing A1 programming through DNA demethylation, but it’s unclear whether chronic disease creates irreversible chromatin states. This determines the therapeutic window and patient selection criteria for epigenetic interventions.

Source: Debate session sess_SDA-2026-04-01-gap-007 (Analysis: SDA-2026-04-01-gap-007)

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