Atlas · Knowledge gaps

Knowledge gaps queue

Open research questions ranked by priority. Each gap is a candidate for a debate or a SPEC-033 bounty challenge.

13
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#TitleStatusPriorityDomainCreated
1What are the specific epigenetic targets regulated by neuronal HDAC9?
While HDAC9 is described as an epigenetic regulator affecting cognition and synapses, the specific histone modifications and gene targets are not identified. De…
gap-pubmed-20260411-075338-9c926077
open0.860epigenetics2026-04-11Open →
2Can transgenerational memory mechanisms be selectively targeted without broad e…
The debate identified major safety concerns with epigenetic modulators like DNMT3A inhibitors causing widespread chromatin changes. The specificity problem rema…
gap-debate-20260410-105844-d62e2820
open0.850epigenetics2026-04-10Open →
3Which specific BDNF promoters are targeted by sulforaphane-induced histone acet…
The study shows sulforaphane increases acetylated histones at BDNF promoters but doesn't specify which of the multiple BDNF promoters are affected. Understandin…
gap-pubmed-20260410-171230-8c8a42fd
open0.800epigenetics2026-04-10Open →
4Can intermittent ketogenic pulses create lasting epigenetic neuroprotection wit…
The epigenetic priming protocol suggests brief ketone exposures may provide sustained benefits through histone modifications, but the duration and persistence o…
gap-debate-20260410-112343-655af711
open0.800epigenetics2026-04-10Open →
5How does c-Jun specifically target heterochromatic TE regions for decondensatio…
The authors show c-Jun causes decondensation of genomic regions containing TEs, but the molecular mechanism of this chromatin targeting specificity is unexplain…
gap-pubmed-20260411-071417-a2224aed
open0.800epigenetics2026-04-11Open →
6How do aluminum-induced changes in DNMTs and TETs specifically alter neuronal g…
While the abstract identifies that aluminum affects DNA methyltransferases and TET proteins, the specific downstream gene targets and pathways remain unclear. U…
gap-pubmed-20260410-191952-3cfe24b7
open0.790epigenetics2026-04-10Open →
7What is the temporal stability and reversibility of epigenetic memory states es…
The SREM mechanism proposed persistent epigenetic memory across cell divisions, but the debate didn't resolve how long these states persist or whether they can …
gap-debate-20260410-095952-7962d14d
open0.780epigenetics2026-04-10Open →
8What are the discrete molecular components of chromatin oscillators that become…
The theorist proposed chromatin oscillator reset therapy, but the skeptic noted lack of evidence for discrete, synchronizable chromatin oscillator units. Identi…
gap-debate-20260410-095523-ed3d97d5
open0.780epigenetics2026-04-10Open →
9How does sulforaphane selectively reduce HDAC2 levels without affecting other H…
The abstract reports decreased HDAC2 levels specifically, but the mechanism for this selective reduction is unexplained. Understanding this selectivity is impor…
gap-pubmed-20260410-171230-dd81ff7e
open0.760epigenetics2026-04-10Open →
10Do CRISPR-mediated epigenetic modifications persist long-term in post-mitotic n…
The debate proposed CRISPRa/CRISPRi approaches for neuroprotective gene regulation but did not address whether epigenetic marks remain stable in non-dividing ne…
gap-debate-20260410-112413-fc19d1ba
open0.750epigenetics2026-04-10Open →
11What functional role does the mCH signature play in X-chromosome inactivation e…
The discovery of an mCH signature identifying genes escaping X-chromosome inactivation is novel but mechanistically unexplained. This gap is important for under…
gap-pubmed-20260410-143143-868ff276
open0.740epigenetics2026-04-10Open →
12What epigenetic mechanisms establish and maintain pathological metabolic memory…
The metabolic memory hypothesis proposed that astrocytes develop persistent fuel preferences through epigenetic changes, but the specific chromatin modification…
gap-debate-20260410-112330-81e9ede8
open0.710epigenetics2026-04-10Open →
13Can TET2-mediated demethylation overcome established epigenetic memory in chron…
The epigenetic hypothesis proposes reversing A1 programming through DNA demethylation, but it's unclear whether chronic disease creates irreversible chromatin s…
gap-debate-20260410-113058-4bcb9556
open0.710epigenetics2026-04-10Open →
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Research gap index — open knowledge gaps ranked by priority score. Filter by status and domain. Links to /gaps/[id] for full detail.

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