Description
The abstract explicitly states that substrates and roles of eight SLC16 family members remain unknown. Given that characterized members transport critical metabolites like lactate and thyroid hormones, these unknown transporters may play important roles in brain metabolism and neurodegeneration.
Gap type: open_question Source paper: The SLC16 gene family - structure, role and regulation in health and disease. (2013, Mol Aspects Med, PMID:23506875)