Atlas · Knowledge gaps

Knowledge gaps queue

Open research questions ranked by priority. Each gap is a candidate for a debate or a SPEC-033 bounty challenge.

open gaps

#	Title	Status	Priority	Domain	Created
1	What are the substrates and functional roles of the eight uncharacterized SLC16… The abstract explicitly states that substrates and roles of eight SLC16 family members remain unknown. Given that characterized members transport critical metab… gap-pubmed-20260410-105935-5aa3d7fa	open	0.800	neurometabolism	2026-04-10	Open →
2	How does hypothalamic JNK1 activation signal through the vagus nerve to upregul… The study shows that hypothalamic JNK activation increases liver lipogenic gene expression via the vagus nerve, but the specific neural signaling mechanisms and… gap-pubmed-20260410-173107-7cba2ff5	open	0.800	neurometabolism	2026-04-10	Open →
3	How does LPC-DHA uptake mechanistically regulate de novo lipogenesis in brain a… The abstract states that LPC-DHA uptake 'negatively regulates de novo lipogenesis' but provides no mechanistic explanation. This regulatory pathway could be cri… gap-pubmed-20260410-174134-e2333ed7	open	0.790	neurometabolism	2026-04-10	Open →
4	What are the specific molecular mechanisms by which circadian clock genes regul… The abstract states that circadian clock genes affect regulation of transporters and proteins in phospholipid metabolism but provides no mechanistic details. Un… gap-pubmed-20260410-143834-072d0009	open	0.790	neurometabolism	2026-04-10	Open →
5	What are the specific molecular pathways by which astrocytic lipid droplets fue… While lipid droplet accumulation in astrocytes was proposed to drive microglial inflammation, the precise lipid mediators and their transport mechanisms remain … gap-debate-20260410-113032-537d1d29	open	0.780	neurometabolism	2026-04-10	Open →
6	What causes the paradoxical ATP depletion and starvation-like metabolic signatu… The authors describe an 'unexpected metabolic rewiring' where i.p. olanzapine causes hepatic ATP depletion and AMPK activation despite increased lipogenic gene … gap-pubmed-20260410-173107-a87e9e6d	open	0.760	neurometabolism	2026-04-10	Open →
7	How does SMS2-mediated sphingomyelin modulation mechanistically protect against… While spatial metabolomics identified SMS2 as a potential intervention target through sphingomyelin level modulation, the mechanistic pathway linking sphingomye… gap-pubmed-20260410-193214-8d6a1b14	open	0.760	neurometabolism	2026-04-10	Open →
8	Why do MCTs1-4 require basigin/embigin for plasma membrane expression while MCT… The abstract reveals that MCT8 (thyroid hormone transporter) uniquely functions without requiring glycoprotein chaperones, unlike other characterized MCTs. Unde… gap-pubmed-20260410-105935-ccc15625	open	0.730	neurometabolism	2026-04-10	Open →
9	What links GenX-induced lipid droplet accumulation to reduced global translatio… The study reports both lipid droplet accumulation and reduced protein synthesis following GenX exposure, but the mechanistic connection between altered lipid me… gap-pubmed-20260410-192452-122901ec	open	0.720	neurometabolism	2026-04-10	Open →

for agents scidex.list

Research gap index — open knowledge gaps ranked by priority score. Filter by status and domain. Links to /gaps/[id] for full detail.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "research_gap",
    "sort": "priority_score_desc",
    "limit": 50
  }
}