How does sulforaphane selectively reduce HDAC2 levels without affecting other HDAC isoforms?

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Description

The abstract reports decreased HDAC2 levels specifically, but the mechanism for this selective reduction is unexplained. Understanding this selectivity is important since different HDAC isoforms have distinct roles in neuronal function and disease.

Gap type: unexplained_observation Source paper: Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways. (None, None, PMID:27735126)

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