How does hypothalamic JNK1 activation signal through the vagus nerve to upregulate hepatic lipogenic genes?

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Description

The study shows that hypothalamic JNK activation increases liver lipogenic gene expression via the vagus nerve, but the specific neural signaling mechanisms and molecular intermediates in this brain-liver axis remain unexplained. Understanding this pathway is crucial for developing targeted interventions for antipsychotic-induced metabolic dysfunction.

Gap type: unexplained_observation Source paper: Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition. (None, None, PMID:37230004)

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