What causes the paradoxical ATP depletion and starvation-like metabolic signature during intraperitoneal olanzapine treatment?

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Description

The authors describe an ‘unexpected metabolic rewiring’ where i.p. olanzapine causes hepatic ATP depletion and AMPK activation despite increased lipogenic gene expression. This counterintuitive metabolic state lacks mechanistic explanation but appears protective against steatosis.

Gap type: unexplained_observation Source paper: Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition. (None, None, PMID:37230004)

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