How does LPC-DHA uptake mechanistically regulate de novo lipogenesis in brain and eye tissues?

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Description

The abstract states that LPC-DHA uptake ‘negatively regulates de novo lipogenesis’ but provides no mechanistic explanation. This regulatory pathway could be critical for understanding metabolic dysfunction in neurodevelopmental and neurodegenerative diseases.

Gap type: unexplained_observation Source paper: Mfsd2a: A Physiologically Important Lysolipid Transporter in the Brain and Eye. (2020, Advances in experimental medicine and biology, PMID:32705603)

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