How does SMS2-mediated sphingomyelin modulation mechanistically protect against DON-induced memory deficits?

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Description

While spatial metabolomics identified SMS2 as a potential intervention target through sphingomyelin level modulation, the mechanistic pathway linking sphingomyelin metabolism to DON-induced synaptic dysfunction remains unclear. Understanding this pathway is critical for developing targeted neuroprotective strategies.

Gap type: unexplained_observation Source paper: Memory impairment mediated by deoxynivalenol via the BLA-PrL circuit. (None, None, PMID:40651373)

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