How does c-Jun specifically target heterochromatic TE regions for decondensation?

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Description

The authors show c-Jun causes decondensation of genomic regions containing TEs, but the molecular mechanism of this chromatin targeting specificity is unexplained. This gap limits understanding of how transcription factors can selectively remodel heterochromatin in disease states.

Gap type: unexplained_observation Source paper: JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease. (2023, Nature communications, PMID:38049398)

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